V. Partali, V. Waagen, T. Alvik
May 1, 1993
Citations
0
Influential Citations
25
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The enzymatic hydrolysis of butanoic esters of 1-phenylmethyl- and 1-[2-phenylethyl] ethers of 3-chloro-1,2-propanediol has been studied by using lipases. Highest enantiomeric ratio was obtained with PPL for the phenylmethyl ether and with Amano SAM II for the phenylethyl ether. The absolute configurations of the products were verified in two ways. Both the produced alcohols and the remaining esters were converted into the corresponding glycidyl ethers which also were synthesised in homochiral forms starting from (S)- epichlorohydrin. The produced alcohols and the remaining esters were prepared independently from (S)-epichlorohydrin.