Sandra S. Ribeiro, C. Raminelli, A. Porto
Oct 1, 2013
Citations
0
Influential Citations
19
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Enzymatic kinetic resolution of organofluorine rac -alcohols by CALB yielded (−)-( R )-2,2,2-trifluoro-1-phenylethanol ( 2a ), (−)-( R )-1-(3-bromophenyl)-2,2,2-trifluoroethanol ( 2b ), (−)-( R )-1-(4-bromophenyl)-2,2,2-trifluoroethanol ( 2c ), (−)-( S )-1-(2,4,5-trifluorophenyl)ethanol ( 2d ), (+)-( S )-2,2,2-trifluoro-1-phenylethyl acetate ( 3a ), (+)-( S )-1-(3-bromophenyl)-2,2,2-trifluoroethyl acetate ( 3b ), (+)- (S )-1-(4-bromophenyl)-2,2,2-trifluoroethyl acetate ( 3c ) and (+)-( R )-1-(2,4,5-trifluorophenyl)ethyl acetate ( 3d ) in high enantiomeric excess (up to >99% ee ). The reactions were conducted under conventional conditions (orbital shaking) and microwave irradiation in toluene and vinyl acetate as acylating agent. The CALB showed excellent selectivities and good yields in the transesterification of fluorinated aromatic compounds.