M. Leeman, F. Querniard, B. Kaptein
Aug 19, 2009
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0
Influential Citations
17
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Journal
Organic Process Research & Development
Abstract
An inexpensive, reliable resolution method for the resolving agent, 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide (phencyphos) was required. Anhydrous phencyphos is a racemic compound, but the hydrate is known to be a conglomerate. After examination of various solvent mixtures a preferential crystallization process in methanol/water solvent mixtures was chosen to deliver the pure enantiomers in good yields. The preferential crystallization process can be repeated up to 50 times without significant loss of efficiency.