Wim A. Starmans, Roy G Doppen, L. Thijs
Feb 13, 1998
Citations
0
Influential Citations
29
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract A facile method for the synthesis of optically active azetidine-2-carboxylic acid derivatives is presented. Racemic N -alkylated azetidine esters are resolved by lipase from Candida antarctica in an ammoniolysis reaction, and both the S- amide and the R -ester are obtained with excellent stereoselectivity.