V. Cesare, R. Stephani
Oct 1, 1997
Citations
0
Influential Citations
4
Citations
Journal
Journal of Chemical Education
Abstract
The resolution of phenylsuccinic acid by salt formation with (-)-proline can be easily used as an undergraduate organic laboratory experiment. Isolation of the (+)-enantiomer can be completed in about two hours and this procedure can also be used to introduce the reflux and recrystallization techniques. This resolution offers several advantages, such as use of relatively nontoxic odorless reagents, high yields of both enantiomers, and a high specific rotation for phenylsuccinic acid.