D. Miller, F. Barkhof, I. Berry
Aug 1, 1991
Citations
9
Influential Citations
401
Citations
Quality indicators
Journal
Journal of Neurology, Neurosurgery & Psychiatry
Abstract
Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated.