D. Hutcheon, L. McCullough
Mar 1, 1952
Citations
0
Influential Citations
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Journal
British journal of pharmacology and chemotherapy
Abstract
Most of the work on the pharmacology of octylamine has been done in connexion with the pressor effects of aliphatic amines. Barger and Dale (1910) found that a comparison of the pressor activity of octylamine, and other members of the series, was difficult because of their cardiac depressant effects. There was no doubt, how-ever, that octylamine had less pressor activity in spinal cats than heptylamine, which in turn was less active than hexylamine. Swanson and Chen (1946) observed that 1-amino-octane did not increase the blood pressure of pithed dogs; 1 mg. of 2-amino-octane, however, caused a rise in pressure equivalent to 0.5 Lg. adrenaline. The respiratory stimulant action of 2-amino-alkanes in dogs under sodium pentobarbitone was observed by Alles (1946), who found that 2-aminoheptane stimulated the respiration more than hexylamine, 2-aminohexane, or 2-aminopentane. Alles also reported that 2-aminoheptane was the most active pressor agent in his series. Charlier (1951) showed that the respirations of dogs under chloralose were stimulated by 2-amino-6-methylheptane and that the stimulation lasted for more than sixty minutes. During the pharmacological 1-amino-octane, it was observed that this amine, when injected into cats under sodium pentobarbitone, lightened the anaesthesia and resulted in deeper and more rapid respirations. analeptic action appeared great enough to warrant further investigation.