Jian Wang, Fengqi Li, Haiming Wei
Nov 17, 2014
Citations
12
Influential Citations
311
Citations
Quality indicators
Journal
The Journal of Experimental Medicine
Abstract
Wang et al. examine how influenza A virus causes GI symptoms. Intranasal infection in mice causes intestinal pathology via virally activated CD4 T cells in the lung up-regulating CCR9 and migrating to the intestine where they secrete IFN-γ that alters homeostasis of the microbiota. Subsequent induction of IL-15 aids differentiation into pathogenic Th17 cells in the gut.