M. Hussain, Alexander J. K. Wilkinson, Vincent W. Bramwell
Nov 19, 2013
Citations
1
Influential Citations
34
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Cationic liposomes of dimethyldioctadecylammonium bromide (DDA) combined with trehalose 6,6′‐dibehenate (TDB) elicit strong cell‐mediated and antibody immune responses; DDA facilitates antigen adsorption and presentation while TDB potentiates the immune response. To further investigate the role of DDA, DDA was replaced with the neutral lipid of distearoyl‐sn‐glycero‐3‐phosphocholine (DSPC) over a series of concentrations and these systems investigated as adjuvants for the delivery of Ag85B–ESAT‐6‐Rv2660c, a multistage tuberculosis vaccine.