H. Schlenk, D. Sand, J. Gellerman
Sep 9, 1969
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Influential Citations
86
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Journal
Biochimica et biophysica acta
Abstract
Abstract 1. 1. Uniformly 14 C-labeled 4,7,10,13,16,19-docosahexaenoic acid was fed to normal rats and to rats at two stages of essential fatty acid deficiency. All groups incorporated about 17% of 14 C fed into liver lipids. Normal rats retroconverted the hexaenoic acid to 7,10,13,16,19-docosapentaenoic and 5,8,11,14,17-eicosapentaenoic acids. These three acids were in phospholipids and, to about 20%, in triglycerides. The deficient rats retroconverted the hexaenoic acid to a much lesser extent and radioactivity in their triglycerides was much lower. 2. 2. The radioactivity in the carboxyl groups of 4,7,10,13,16,19-docosahexaenoic and 5,8,11,14,17-eicosapentaenoic acids corresponded closely to an even distribution of 4 C in the chain. However, radioactivity in the carboxyl group of 7,10,13,16,19-docosapentaenoic acid was much lower than calculated for even distribution. At least 75% of this acid must have been reconstituted from a C 20 chain.