D. Patel, D. Ryono
Sep 1, 1992
Citations
0
Influential Citations
5
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Application of the retro-inverso peptide backbone modification concept to the tripeptide alcohol renin inhibitor Boc-Phe-His-Leucinol 1 (I 50 = 16 uM) is described. While the diastereomeric mixture of partial retro analogs 3ab was substantially less active (I 50 = 1200 uM), the complete retro-inverso modification was well tolerated, as evidenced by the equipotency of 2b (I 50 = 20 uM) to parent compound 1 .