R. Calvino, R. Fruttero, A. Gasco
Jun 28, 1991
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0
Influential Citations
9
Citations
Journal
Journal of Chromatography A
Abstract
Abstract The lipophilicity of a series of para- and meta-substituted phenyl-ONN-azoxycyanides, analogues of the antibiotic ‘calvatic acid’, was studied by reversed-phase high-performance liquid chromatography using methanol—water or acetonitrile—water as the mobile phase and a LiChrospher 100 RP-18 column. An excellent linear relationship between the logarithm of the capacity factors (log k′) for each compound and the volume fraction of the organic modifier (ϕ) was found. The extrapolation of log k′ to ϕ = 0 gives log kw for every compound. From these values τw constants were calculated for each substituent. Good correlations were found between log kw and log Poct/H2O and between τw and Hansch's π hydrophobic parameter.