P. Lehtonen
1983
Citations
0
Influential Citations
10
Citations
Journal
Journal of Chromatography A
Abstract
Abstract The reversed-phase liquid chromatographic retention of sixteen N-ethylbenzamides substituted with methyl, methoxy or phenyl groups at the 4-phenyl position and/or at the 2-ethyl position was investigated using two different octadecyl phase columns and a phenyl phase column with water—methanol solvent mixtures. For isomeric amides an increased retention was obtained for the isomer having the larger substituent at the 4-phenyl position. Satisfactory linear correlations were obtained by plotting log k′ obtained on one column against log k′ on a second column at the same or different eluent compositions. This suggests that quantitative structure—retention relationships can be transformed from one reversed-phase system to another. The molecular connectivity indices, χ, to third order were calculated for the amides, and a high degree of correlation was observed between them and the measured log k′.