Du Biao
2010
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Chinese Journal of New Drugs and Clinical Remedies
Abstract
AIM To compare the difference in clinical efficacy and adverse reactions between amfebutamone and fluoxetine.METHODS A total of 9 papers about controlled study comparing amfebutamone with fluoxetine in treatment of depression retrieved were subjected to a system evaluation.RESULTS There was no significant difference on clinical efficacy between amfebutamone and fluoxetine [P 0.05,OR = 1.14,95%CI(0.87-1.49) ].The incidences of adverse reactions such as excitation or agitation in fluoxetine group were significantly higher than that of amfebutamone group(χ2 = 5.66,P 0.05),and the incidences of adverse reactions such as akathisia in the amfebutamone group were significantly higher than that of the fluoxetine group(χ2 = 9.96,P 0.01).There was no significant difference of others adverse events between the two groups.CONCLUSION Amfebutamone is similar to fluoxetine in efficacy and adverse reactions,and it is an effective and safe drug for depression.