A. Skarbek, Michael Jacobsen
Dec 1, 1965
Citations
1
Influential Citations
34
Citations
Quality indicators
Journal
British Journal of Psychiatry
Abstract
Oxypertine (also known as WIN 18,501–2) is a member of a new series of indolylalkylphenyl-piperazines synthesized by Archer et al (1). It resembles serotonin in respect of its indole nucleus, and the piperazine side-chain indicates a structural relationship with some of the major phenothiazines. Pharmacological studies by Wylie and Archer (17) showed oxypertine to have tranquillizing properties, and following preliminary human tolerance investigations (15) the psychotherapeutic nature of the agent was investigated by various workers in the United States and Europe.