Duan Jing-li, Li Quan-zhi
2010
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Influential Citations
2
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Quality indicators
Journal
China Pharmacy
Abstract
OBJECTIVE: To evaluate the efficacy and safety of diammonium glycyrrhizinate in the treatment of drug-induced liver injury according to present clinical studies. METHODS: Retrieved from CBM and the CNKI from 1994 to 2009, literatures about the randomized controlled trials that the effective rate of diammonium glycyrrhizinate was compared with that of other hepatoprotective with drug-induced liver injury and drug-induced liver disease as study subjects. RESULTS: 18 RCTs including 1,644 patients with drug-induced liver injury were enrolled. The effective rate of diammonium glycyrrhizinate group was higher than that of control group, statistical significance was noted in two groups (P0.05). There was no statistical significance between two groups in respect of adverse drug reaction and reduction of biochemical indicators such as ALT, AST and TBIL (P≥0.05). CONCLUSION:Results of systematic review demonstrate that diammonium glycyrrhizinate has better effect than other hepatoprotective on drug-induced damage of liver function.