Salahuddin, Km Shabana, A. Mazumder
Oct 17, 2022
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Journal
Letters in Drug Design & Discovery
Abstract
Benzimidazole (Benz-fused bicyclic ring system) is the most versatile class of heterocyclic compounds due to their numerous applications in industrial and synthetic organic chemistry because of its many biological actions. Benzimidazole analogs have been utilized to discover a variety of medical problems, such as cancer, bacterial infections, fungal infections, etc. Nitrogen-containing hybrid heterocyclic compounds are being studied by researchers because it provides a broad range of therapeutic potential and has minimal side effects. The current review of the literature emphasizes recent developments in the design of new benzimidazole derivatives as possible anticancer agents with their relationship between structure and activity, which will give insight into the future design of more active benzimidazole molecules. The present review consists of synthetic protocols for the synthesis of benzimidazole derivatives along with their pharmacological potentials and structure-activity relationship in correlation with synthetic molecules to provide a depth view of the work done on benzimidazole. It would be significant for further research in the development of better drug molecules representing a potent derivative of medicinal agents.