Xu Yun-gen
2008
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Quality indicators
Journal
Progress in Pharmaceutical Sciences
Abstract
FTY720,2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride,is an oral sphingosine-1-phosphate receptor agonist and immunosuppressant being developed for anti-rejection in organ transplantation,autoimmune disorders,tumor and inflammatory diseases.Phase III clinical trial of FTY720 in the treatment of graft rejection episodes after renal transplantation and phase II clinical trial in the treatment of multiple sclerosis are underway.The recent developments of FTY720 and its analogs were reviewed.