Aderonke Av, Dede Ah, Oluwatobi Ai
Dec 31, 2020
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Journal
Journal of Translational Science and Research
Abstract
Metal complexes are fundamentally known to be engendered in biological systems from reaction between a ligand and a metal ion in dynamic equilibrium. This review aims at examining the metal complexes of Nickel (II) salicylhydroxamic acid and its aniline adduct. It is imperative to reiterate that Nickel which is a chemical element with the symbol Ni, and atomic number 28, silvery-white lustrous metal with a slight golden tinge, is the only material magnetic in nature, and as such its combination with other distinct molecules such as aniline produces unique results. As such, this review focuses extensively on studies that revolve around nickel its structure importance, aniline and its derivatives, and the metal complex of both materials. In fact, the potential for nickel and its adduct to serve as an alternative antibiotic therapy as suggested in previous studies was also highlighted as the increasing development of drug resistance, as well as the appearance of undesirable side effects of certain antibiotics has led to the search for new antimicrobial agents with the goal to discover new chemical structures, which overcome the above disadvantages. In conclusion, review of the synthesis, spectroscopy and antimicrobial activity of Nickel (II) Salicylhydroxamic acid, and its aniline adduct unveils the possibility of developing new drugs to improve upon the current resistance-prone antimicrobial therapeutic agents available.