N. JeelanBasha, N. Goudgaon
Dec 15, 2021
Citations
1
Influential Citations
35
Citations
Quality indicators
Journal
Journal of Molecular Structure
Abstract
Abstract Pyrimidines are nitrogen-containing heterocycles known for anticancer, anti-HIV, antifungal, and antibacterial activities. Pyrimidines, compounds bearing this heterocycle, are common in many medicinal drugs. Based on these findings, we have also reported the synthesis and biological activities of potential pyrimidine analogs. This review article provides a comprehensive insight into clinically approved pyrimidine-containing drugs and recent reports based on the broad-spectrum activities of pyrimidine analogs. Further, this review highlights the main aspects of pyrimidine analogs such as anticancer, sedative, antibiotic, antiviral, anti-inflammatory, analgesics, and anti-microbial activities, that make this molecule a more attractive scaffold for the discovery of newer drugs.