V. Sharma, A. Barde, S. Rattan
Oct 7, 2020
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Influential Citations
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Quality indicators
Journal
Synthetic Communications
Abstract
Abstract Glitazones are an important class of prescription drugs used to treat type II diabetes (T2DM). These drugs reduce blood sugar levels by targeting the peroxisome proliferator-activated receptors (PPARs) and act as insulin sensitizers. There are currently several FDA-approved glitazones. This review describes the synthetic strategies used for manufacturing of these drugs, in particular focusing on synthesis by commercially available thiazolidine-2,4-dione (TZD) on both bench and industrial scales. Further, an insight into the chiral approaches reported for enantiomers of pioglitazone and rosiglitazone is given. A brief description about the history of glitazones is also provided. This short review is aimed at providing a holistic understanding of the challenges and issues associated with implementing an effective strategy for synthesis of these drugs. Graphical Abstract