M. Maheshwari, A. Goyal
Mar 1, 2015
Citations
0
Influential Citations
9
Citations
Journal
Asian Journal of Pharmaceutical and Clinical Research
Abstract
The ultimate beneficiary of scientific advances is discovering new and better therapeutic agents. 1,4-benzothiazine forms an important class of heterocyclic system, contains both N and S. Consequently, there have been various efforts for the production of novel 1,4-benzothiazine derivatives possessing various biological activities such as anti-hypertensive, anti-HIV, anti-inflammatory, antimicrobial, anti-rheumatic, ATP-sensitive potassium channel opener, cardiovascular, cytotoxic, immunomodulator, neuroprotective, antioxidant, antimalarial and aldose reductase inhibitor etc. As a part of an ongoing effort toward finding novel pharmacological active agents, it was thought worthwhile to synthesize hybrids of 1,4-benzothiazine. Keywords: 1,4-Benzothiazine, Ring expansion reaction, Biological activity, 2-aminothiophenol.