N. Murakami, Y. Ye, M. Kawanishi
Oct 21, 2002
Citations
1
Influential Citations
63
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells.