Xu Xu, Guanyu Zhou, Guodong Ju
Aug 4, 2021
Citations
0
Influential Citations
6
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract Here, a rhodium(III)-catalyzed benzo[c]azepine-1,3(2H)-dione synthesis via tandem C–H alkylation and intramolecular amination of N-methoxylbenzamide with 3-bromo-3,3-difluoropropene as the alkylation agent is reported. The substituted benzamides and protected indoles are all tolerated, yielding the corresponding products in moderate to good yields. Further study revealed those bioactive compounds such as piperic acid and a key precursor of Roflumilast all perform well, highlighting the synthetic utility of this method.