Lotte Coelmont, J. Paeshuyse, M. Windisch
Oct 1, 2006
Citations
4
Influential Citations
59
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
ABSTRACT Ribavirin antagonizes the in vitro anti-hepatitis C virus (HCV) activity of the pyrimidine nucleoside analogue 2′-C-methylcytidine, the active component of the experimental anti-HCV drug valopicitabine. In contrast, the combination of ribavirin with either the purine nucleoside analogue 2′-C-methyladenosine or the HCV protease inhibitor VX-950 resulted in an additive antiviral activity. These findings may have implications when planning clinical studies with valopicitabine.