Anne Cochi, Benjamin Burger, C. Navarro
Aug 1, 2009
Citations
0
Influential Citations
10
Citations
Journal
Synlett
Abstract
A very short route to 2-phenylpiperidin-3-ol derivatives and 3-hydroxypipecolic acids is described. The approach uses two key steps: a one-pot reduction/Grignard addition sequence applied to alkyl proline esters and a ring expansion applied to the corresponding prolinols.