P. Lont, H. Plas, A. Verbeek
Sep 2, 2010
Citations
0
Influential Citations
9
Citations
Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
It has been found that 2-chloropyrazine, containing an excess of 15N in position 1, by treatment with potassium amide in liquid ammonia at −65° yields 2-aminopyrazine, in which the exocyclic nitrogen contains all the excess of 15N. An A(ddition)-N(ucleophilic)-R(ing)-O(pening)-R(ing)-C(losure) mechanism is proposed. The corresponding animation of 2-chloro[1(4)-15N]quinoxaline at −33° leads to 2-amino[1(4)-15N]quinoxaline. In the last-mentioned conversion an A(ddition)-E(limination) mechanism is operative.