M. Scheunemann, D. Sorger, E. Kouznetsova
Jul 30, 2007
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A modular approach to novel 6-amino-7-hydroxysubstituted hexahydro-benzo[1,4]oxazin-3-ones has been developed. The method involves a sequential ring-opening of trans-1,4-cyclohexadiene dioxide with amino nucleophiles. The resultant mono-epoxide from benzylamine was converted to a general electrophilic precursor, which enables the parallel treatment with amino nucleophiles to obtain a series of cyclohexane-fused morpholin-3-ones.