Yuh-meei Lin, D. Zembower, M. Flavin
Sep 9, 1997
Citations
0
Influential Citations
20
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Robustaflavone, a naturally occurring biflavanoid isolated from the seed kernel extract of Rhus succedanea, was found to be a potent in vitro inhibitor of hepatitis B, with an effective concentration (EC50) of 0.25 μM and an in vitro selectivity index ( IC 50 EC 90 ) of 153. Further studies suggested that inhibition of HBV DNA polymerase is the mechanism of action.