M. Turck, F. Silverblatt, H. Clark
Sep 1, 1970
Citations
0
Influential Citations
16
Citations
Journal
The Journal of infectious diseases
Abstract
New antimicrobial agents effective in the treatment of gram-negative bacterial infections of the urinary tract have been sought continually. This has been especially true of infections caused by Pseudomonas aeruginosa and Proteus species, which are often resistant to a number of existing antimicrobial agents. Carbenicillin (disodium carboxybenzyl penicillin) is a semi-synthetic penicillin that is active in vitro against many strains of P. aeruginosa as well as members of the Enterobacteriaceae [1-3] and which, because of its low toxicity, may be useful in diverse infections produced by gram-negative bacteria. The present communication describes the in-vitro effects of carbenicillin against 180 bacterial isolates and deals with the use of this agent in treatment of 22 patients with infection of the urinary tract.