M. Glovsky, P. Ward, H. Fudenberg
1973
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Clinical immunology and immunopathology
Abstract
Abstract Two complement (C) inhibitors, the cobra venom C3 inactivator and fumaropimaric acid were used to study skin allograft rejection in the guinea pig. The cobra venom inactivator markedly lowered C activity. When injected on Day 5 post-allograft, the venom factor induced a 2- to 3-day prolongation of allograft survival. Fumaropimaric acid, a reversible inhibitor of C1, C2, C3, C 567 is known to have only a transient complement inhibitory effect. When injected in divided doses from Days 5–7, little if any prolongation of allograft rejection was noted. Serum hemolytic complement activity was not reduced during normal allograft rejection, nor could C3 be found bound to allograft rejection sites by immunofluorescence. It is suggested that the cobra venom C3 inactivator prolongs allograft survival by alteration of complement-dependent inflammation.