O. Neuhaus, B. Kieseier, H. Hartung
2006
Citations
4
Influential Citations
80
Citations
Quality indicators
Journal
Pharmacology & therapeutics
Abstract
Mitoxantrone is approved by several health authorities for treatment of active forms of relapsing-remitting or secondary progressive multiple sclerosis (SPMS). This review provides an outline on relevant preclinical as well as clinical studies, places mitoxantrone in the context of other therapeutic approaches against multiple sclerosis (MS), and discusses relevant side effects. The current knowledge of the putative mechanisms of action of the compound is discussed.