C. Estler, R. Böcker
Jul 1, 1980
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0
Influential Citations
11
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Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract The effect of rolitetracycline on the hepatic accumulation of lipids was studied in male and female NMRI mice. In both sexes rolitetracycline (50 mg/kg, iv) caused an increase of hepatic triglyceride content that was maximal after 4 hr, but in male animals this effect was small and short lasting as compared to females. In females rolitetracycline inhibited the hepatic release of esterified fatty acids to a much greater extent than in males. Correspondingly, a concomitant decrease in serum esterified fatty acids could be observed only in females. Hepatic cholesterol and phospholipids decreased in females and to a lesser degree in male mice. There were no consistent changes in the hepatic content of ATP, lactate, pyruvate, and glutathione and in serum nonesterified fatty acids. These results suggest that rolitetracycline produces steatosis mainly by impairing the outward transport of triglycerides from the liver and that sex hormones play a vital but yet unknown role in this effect.