Cyrus A. Anderson, Phillip G. Taylor, Mary A. Zeller
Jul 16, 2010
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0
Influential Citations
21
Citations
Journal
The Journal of organic chemistry
Abstract
Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu(2)O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.