A. Zouitini, Y. Rodi, H. Elmsellem
Jun 10, 2017
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Journal
Moroccan Journal of Chemistry
Abstract
In this paper we describe the synthesis of new quinoxalines which can present a potential pharmacological properties The 6-methyl-1,4-dihydroquinoxaline-2,3-dione 3 was synthesized by the condensation of 4-methyl- o -phenylenediamine 1 with oxalic acid 2 under reflux in hydrochloric acid solution.Compound 3 was exposed to alkylation reactions under the conditions of phase transfer catalysis using monohalogenated agents leading to alkylated products 3a-3f . Structures of the obtained products were confirmed by spectroscopic measurements.