Martin Gazvoda, Marko Krivec, Zdenko Časar
Feb 7, 2018
Citations
1
Influential Citations
7
Citations
Journal
The Journal of organic chemistry
Abstract
A six-step synthetic route from 4-chloro-2-methylaniline to 5-chloro-2-(cyclobut-1-en-1-yl)-3-(trifluoromethyl)-1H-indole (1) has been reported. Compound 1a is a key impurity of reverse transcriptase inhibitor efavirenz, an important anti-HIV/AIDS drug. Synthetic challenges, dead ends, and detours are discussed.