P. Klein, G. Boons, G. Veeneman
1989
Citations
0
Influential Citations
50
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Treatment of 2,3:5,6-di-O-isopropylidene-D-mannitol with thionyl chloride followed by oxidation gave the corresponding 1,4-cyclic sulfate. Ring opening of the cyclic sulfate with the anion of ethyl 1,3-dithiane-2-carboxylate, and subsequent acidolysis and unmasking of the thioketal, afforded ethyl 4,5:7,8-di-O-isopropylidene-3-deoxy-α(β)-D- manno -2-octulosonate in an excellent yield.