F. Trécourt, A. Turck, N. Plé
May 1, 1995
Citations
0
Influential Citations
12
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Starting from 3,6-dichloropyridazine, a new route is described to antihypertensive 5,6-diarylpyridazin-3-ones. This pathway comprises the regioselective metalation followed by a substitution of the trimethylsilyl moeity. The introduction of iodine by another metalation allowed the cross coupling of arylboronic acids. The 6-methoxy group was then cleaved to afford the pyridazinones.