Z. Zhe
2010
Citations
0
Influential Citations
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Citations
Journal
Heilongjiang Medicine and Pharmacy
Abstract
Objective:To synthesize a key intermediate of anti-hypertension drug Losartan,2-butyl-4-chloro-5-formylimidazole(1).Methods:1-methoxy-1-imine pentane(2) was synthesized with methanol and valeronitrile as raw materials,catalyzed with sodium methoxide,and after substitution,by cyclization to obtain 2-butyl-4-chloro-5-formylimidazole(1).Conclusion:This route was suitable for the large-scale preparation with its high yields(59.02%),mild reaction conditions,easily available materials.