M. Vosooghi, Hossein Arshadi, Mina Saeedi
May 1, 2014
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Influential Citations
4
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Journal
Journal of Fluorine Chemistry
Abstract
Abstract In this paper, we report a novel and efficient route for the synthesis of 5-nitrobenzoxazole derivatives starting from 2-fluoro-5-nitroaniline and various benzoyl chloride derivatives under solvent-free conditions at 130 °C in the presence potassium carbonate. Benzoyl chlorides easily underwent nucleophilic acyl substitution followed by intramolecular cyclization via concomitant removal of fluorine to obtain the title compounds in high yields.