O. Goj, G. Haufe
Jan 25, 2006
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Liebigs Annalen
Abstract
2-Fluoro-2-phenylalkanoic acids 2 are obtained by oxidation of the corresponding β-fluoro-β-phenyl alcohols 6. These compounds are shown to be accessible by two alternative pathways, either by bromo fluorination of α-alkyl styrenes 3, subsequent bromine-by-acetate replacement in the bromo fluorides 4 and hydrolysis of the acetates 5 or by a BF3 · OEt2 catalyzed ring opening of corresponding styrene oxides 8 with triethylamine tris(hydrofluoride).