C. Bamford, I. Middleton, K. Al-Lamee
May 1, 1987
Citations
0
Influential Citations
17
Citations
Journal
Polymer Journal
Abstract
The reactions employed for coupling anti-platelet and other drugs to hydroxylic polymers are described. The drugs include the prostaglandin analogue 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW 245C) and the phosphodiesterase inhibitors dipyridamole and theophylline. Polymers studied were poly(vinyl alcohol), dextran, and poly(ethylene glycol), and coupling was effected either with the aid of halo-isocyanates or by a two-stage process using carbonyl diimidazole. These novel reaction sequences appear to have wide applications. Some data are presented on the inhibition of platelet aggregation by the free and coupled drugs.