A. Katritzky, S. Rachwał, R. Ollmann
Jul 1, 1994
Citations
0
Influential Citations
12
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The use of intermediate benzotriazol-1-yl derivatives simplified the procedures for the preparation of 5-methoxy-1-methylbenzimidazole and 6-methoxy-1-methylbenzimidazole starting from 4-methoxy-2-nitroaniline. This strategy represents a novel and potentially general method for synthesis of 5- and 6-substituted-1-methylbenzimidazoles from 4-substi- tuted anilines. Preparation of 1-methyl-5-nitrobenzimidazole by reaction of 2-chloro-5-nitroaniline with methylamine and condensation of the obtained diamine with formic acid represents a special case