N. Kandepu, Sharadamma C. Kodaganur, A. Mantri
Jan 15, 2012
Citations
0
Influential Citations
5
Citations
Journal
Eurasian Journal of Analytical Chemistry
Abstract
Halquinol is a mixture obtained by chlorinating 8-Hydroxy quinoline. It contains 5,7-dichloroquinolin-8-ol (57 to 74%), 5-chloroquinolin-8-ol (23 to 40%), and 7- chloroquinolin-8-ol (up to 4%). It is an antibacterial, antifungal and antiprotozoal in nature, and is used in many areas of the world in poultry and swine rearing to fight microbial infections and in growth promotion. A simple, rapid, economic, accurate reverse phase isocratic HPLC method was developed for quantification of Halquinol in different dosage forms such as suspension and bolus. The method was validated with respect to linearity, precision, accuracy and robustness. The calibration curve was linear in the range of 12-28 µg/mL -1 for 5-chloroquinolin-8-ol and 33-77 µg/mL -1 for 5,7-dichloroquinolin-8-ol respectively. The method has been successfully applied for the analysis of Halquinol in pharmaceutical dosage forms.