A. Spinedi, L. Pacini, P. Luly
1993
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Abstract
Rubidium (Rb+) has been used for many years in the control of endogenous depression (Meltzer et al. 1969; Fieve et al. 1971; Fieve and Meltzer 1974; Sarteschi et al. 1984), despite the fact that its mechanism of action is still unknown. In fact, it has been found to produce therapeutic effect in 65% of patients with endogenous depression (Carolei et al. 1975); also in bipolar patients Rb+ was shown to decrease both the duration and severity of depressive episodes (Fieve 1976).