Chuan-Jun Lu, Zonghua Luo, Ling Huang
Apr 11, 2011
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The asymmetric transfer hydrogenation of a series of halo-substituted aryl methyl ketones, including those substituted in both α-methyl and aryl rings, was studied for the preparation of chiral halohydrins. Up to 99.7% ee was obtained with 2-chloro-1-(2-chlorophenyl)ethanone as the substrate and Ru-CsDPEN as the catalyst in an HCOONa/H 2 O system. ( R )-Clorprenaline , a drug used in the treatment of respiratory disorders, such as bronchitis and asthma, and ( S )-sotalol, a class-III antiarrhythmic compound, were prepared with these chiral halohydrins.