Huaxing Zhang, Yuhong Zhang, Leifang Liu
Jul 13, 2005
Citations
1
Influential Citations
40
Citations
Journal
Synthesis
Abstract
The 1,4-conjugate addition of primary, secondary and aromatic amines, thiols, and carbamate to α,β-unsaturated compounds mediated by a catalytic amount (0.5 mol%) of RuCl 3 in poly(ethylene glycol) (PEG) provides the desired β-substituted carbonyls in high yields. In particular, we found that primary aliphatic and aromatic amines produced the single adducts as the sole products in very high yields with RuCl 3 -PEG. RuCl 3 -PEG was readily recycled via solvent precipitation with efficient recyclability as evidenced by high yields. Its properties of low sensitivity toward moisture and oxygen, high tolerance of different functional groups, and efficient recyclability make RuCl 3 -PEG suitable for both laboratory and industrial scale synthesis of β-substituted carbonyls.