Y. Yasaka, Y. Ono, M. Tanaka
Jun 12, 1998
Citations
0
Influential Citations
17
Citations
Journal
Journal of Chromatography A
Abstract
A new triflate-type fluorescence chiral derivatizing reagent, (S)-(+)-1-methyl-2-(6,7-dimethoxy-2,3-naphthalimido)ethyl trifluoromethanesulfonate, [S-(+)-MDNE-OTf], has been developed for the determination of the enantiomers of carboxylic acids. By introducing the two methoxy groups on the naphthalimido ring moiety, the red shift in the fluorescence spectrum and a high resolution in reversed-mode separation of the diastereomers of chiral carboxylic acids have been achieved. The detection limits (S/N=3) with ultraviolet and fluorescence detection are 8 fmol (λmax=283 nm) and 4 fmol (λex=283 nm, λem=467 nm), respectively.