Vladimir S. Yarmolchuk, A. V. Bezdudny, N. A. Tolmacheva
Apr 1, 2012
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Journal
Synthesis
Abstract
trans-2-(Trifluoromethyl)cyclopropylamine was prepared on a multigram scale from readily accessible 4,4,4-trifluorobut-2-enoic acid in five steps. The key step was a high-yielding cyclopropane ring formation from 4,4,4-trifluorobut-2-enoic acid methoxymethyl amide under Corey-Chaykovsky reaction conditions.