F. Zaragoza, A. Gantenbein
Feb 17, 2017
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0
Influential Citations
4
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Journal
Organic Process Research & Development
Abstract
The treatment of ethyl 2-hydroxyimino-4,4,4-trifluoro-3-oxobutanoate (3) with trialkyl phosphites, ethylenediamine, and an excess of a carboxylic acid in pyridine or picoline leads to the formation of an intermediate, which can be aromatized to a pyrazine by treatment with bromine or other oxidants. This synthesis can be performed either with the isolated oxime 3 or from ethyl 4,4,4-trifluoro-3-oxobutanoate (1) in a one-pot fashion, without any solvent change and without having to isolate any intermediates.